SS
Suzanne Scott
Children's Medical Research Institute, Commonwealth Scientific and Industrial Research Organisation, University of Oxford, The University of Queensland
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Virus-based gene therapy research · RNA Interference and Gene Delivery · Neuroscience and Neuropharmacology Research
0000-0002-5830-8943
Employment
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Children's Medical Research Institute Research Officer2022 - Present
Education
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University of Oxford DPhil2015 - 2019
- 2014 - 2015
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University of Queensland BSc (Hons.)2010 - 2013
Projects & Funding
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Developing a promoter-less gene therapy approach for haemophilia A Medical Research Future Fund2022 - 2025
Publications (35)
- AAV-mediated XIST deletion in female human hepatocytes with skewed X-inactivation induces limited reactivation of the X-linked OTC gene in vivo Save
- Identification of AAV vector integration sites in primary human and macaque hepatocytes in vivo and analysis of oncogenic risk Save
- Determining the molecular and physiological actions of subtype-selective nanobodies of GABA-A receptors Save
- Tailoring capsid-directed evolution technology for improved AAV-mediated CAR-T generation Save
- AAVolve: Concatenated long-read deep sequencing enables whole capsid tracking during shuffled AAV library selection Save
- Development of CNS tropic AAV1-like variants with reduced liver-targeting following systemic administration in mice Save
- Enhanced AAV transduction across preclinical CNS models: A comparative study in human brain organoids with cross-species evaluations Save
- Novel AAV variants with improved tropism for human Schwann cells Save
- Assessment of Pre-Clinical Liver Models Based on Their Ability to Predict the Liver-Tropism of Adeno-Associated Virus Vectors Save
- Characterization of the humanized FRG mouse model and development of an AAV-LK03 variant with improved liver lobular biodistribution Save
- Development of new adeno-associated virus capsid variants for targeted gene delivery to human cardiomyocytes Save
- A bioinformatic pipeline for simulating viral integration data Save
- Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV vectors Save
- Isling: A Tool for Detecting Integration of Wild-Type Viruses and Clinical Vectors Save
- Novel human liver-tropic AAV variants define transferable domains that markedly enhance the human tropism of AAV7 and AAV8 Save
- Pipeline for simulating integrations Save
- Finding integrations of a clinical gene therapy vector in NGS data with isling Save
- Cloud-based Machine Learning for Genome Engineering Save
- isling: a tool for identifying integration sites in sequence data Save
- Scaling Machine Learning to Uncover the Genome’s Role in Complex Diseases Save