Jonathan C. K. Quirke

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Publications (4)

• Commonality of Mechanism in Glycoside Hydrolases, Nucleoside Hydrolases, and Phosphorylases: Importance of Side-Chain Conformation Preorganization
  Po‐Sen Tseng, Jonathan C.K. Quirke, Winston C. Lin +1 more
  JACS Au 2025 DOI: 10.1021/jacsau.5c01069
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• Structure‐Activity Relationships for 5′′ Modifications of 4,5‐Aminoglycoside Antibiotics
  ChemMedChem 2022 DOI: 10.1002/cmdc.202200120
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• GH47 and Other Glycoside Hydrolases Catalyze Glycosidic Bond Cleavage with the Assistance of Substrate Super-Arming at the Transition State
  ACS Catalysis 2021 DOI: 10.1021/acscatal.1c02750
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• Glycoside Hydrolases Restrict the Side Chain Conformation of Their Substrates To Gain Additional Transition State Stabilization
  Journal of the American Chemical Society 2020 DOI: 10.1021/jacs.0c05592
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