Mark Joseph Koonthanam Chandy
Western University, University of Toronto, Stanford University, University of British Columbia, Pennsylvania State University
Research areas: Biochemistry, Genetics and Molecular Biology · Cancer Research · MicroRNA in disease regulation · Cannabis and Cannabinoid Research · Atherosclerosis and Cardiovascular Diseases
About
Dr. Chandy earned his MD and Ph.D. in 2008, at Pennsylvania State University. After completing medical school, Dr. Chandy trained in Internal Medicine at the University of British Columbia, followed by a Cardiology fellowship at the University of Toronto. He also completed a fellowship in Echocardiography and enrolled in the Clinician Scientist Training Program at the University of Toronto. With a desire to learn stem cell biology, Dr. Chandy trained in induced pluripotent stem cells (iPSCs) disease modeling at Stanford University. As a recently appointed Assistant Professor at the University of Western Ontario, Dr. Chandy is an independent physician-scientist using iPSC disease modeling, next-generation sequencing (NGS), proteomics, and gene editing to understand the mechanisms of cardiovascular disease. Dr. Chandy's current research focuses on understanding the pathophysiology of environmental exposures such as air pollution, e-cigarettes, and cannabis on cardiovascular disease using human iPSC-derived tissue.
Employment
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Western University Assistant Professor2021 - Present
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University of Toronto Echocardiography Fellowship2014 - 2016
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University of Toronto Cardiology Resident2011 - 2014
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University of British Columbia Internal Medicine Residency2008 - 2011
Education
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Stanford University Postdoctoral Fellow2016 - Present
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University of Toronto Postdoctoral Fellowship2014 - Present
- 2000 - 2008
- 2000 - 2008
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University of Toronto M. Sc.1998 - 2002
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University of Toronto H. B. Sc1994 - 1998
Projects & Funding
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Detweiler Traveling Award Royal College of Physicians and Surgeons2016 - 2018
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Ministry of Health Clinician Investigator Program Ontario Ministry of Health and Long-Term Care2015 - 2016
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Clinician Scientist Training Program University of Toronto2014 - 2017
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Medical Scientist Training Program NIH Clinical Center2000 - 2008
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Characterization of the Zebrafish homolog of Fushi Tarazu Factor-1 Bombardier1998 - 2000
Publications (66)
- Targeting an Atypical GPCR Signaling Pathway for Cardiac Fibrosis Therapy Save
- Δ 9 -THC Promotes Profibrotic Cell States In Vitro and Impairs Vascular Function In Vivo Save
- Cannabis Is Not Vascularly Inert: Proatherogenic Inflammation in Youth Save
- 1425-P: Modelling Vascular Dysfunction in Lean Type 2 Diabetes Using IPSC-Derived Endothelial Cells Under Metabolic Stress Save
- Harnessing iPSCs to Model Marfan Syndrome: Advancing Clinical Diagnosis and Drug Discovery Save
- Cardiac fibrosis: from mechanisms and models to medicines Save
- Abstract Or202: Multiscale Platform Identifies Novel Therapeutic Targets for Fibrosis Save
- The relationship between cannabis and cardiovascular disease: clearing the haze Save
- Specialized pericyte subtypes in the pulmonary capillaries Save
- Transcriptomic analysis of nicotine on the cardiovascular system using a diverse population of human induced pluripotent stem cell-derived endothelial cells Save
- The effects of cannabinoids on the kidney Save
- Addressing Cardiovascular Toxicity Risk of Electronic Nicotine Delivery Systems in the Twenty-First Century: “What Are the Tools Needed for the Job?” and “Do We Have Them?” Save
- Elucidating effects of the environmental pollutant benzo[a]pyrene [BaP] on cardiac arrhythmogenicity. Save
- Recent advances in the cardiotoxicity of anti-cancer drugs: Navigating the landscape of anthracycline-induced cardiotoxicity. Save
- Adverse Impact of Cannabis on Human Health. Save
- Exosomes and lipid metabolism in metabolic and cardiovascular disorders. Save
- SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant Save
- Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling Save
- Adverse effects of air pollution‐derived fine particulate matter on cardiovascular homeostasis and disease Save
- Abstract P3005: Cannabinoid Receptor 1 Antagonist Genistein Attenuates Marijuana-Induced Vascular Inflammation Save