ME
Michael Eccles
University of Otago
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Epigenetics and DNA Methylation · Renal and related cancers · Genomics and Chromatin Dynamics
0000-0002-6824-8761
Employment
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University of Otago Chair in Cancer Pathology2006 - Present
Education
Education history is unavailable.
Projects & Funding
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From friend to foe: How do cancer cells convert the p53 tumour suppressor gene into an oncogene? Marsden Fund2020 - 2023
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Characterizing the role of a newly identified peroxidase in melanoma Marsden Fund2019 - 2022
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Epigenomic profiling to predict patient response to melanoma immunotherapy Health Research Council of New Zealand2018 - 2021
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The genes of life and death: a role for placental-specific genes in cancer? Marsden Fund2017 - 2020
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The genes of life and death: a role for placental-specific genes in cancer? Marsden Fund2017 - 2020
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Using circular polarised light to evaluate cell differentiation status in vivo Health Research Council of New Zealand2013 - 2015
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Strategic targets for cancer therapy and proliferative disorders James Cook Research Fellowship2000 - 2002
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IDENTIFYING TRANSFORMING GENES IN MONOCYTIC TUMORS Fogarty International Center1988 - 1988
Publications (27)
- Transcriptional Activation of Transposable Element (TE)-Associated Genes Is Frequently Associated with Altered Promoter Methylation in Placenta and Melanoma Save
- Epigenetic Deregulation of Transposable Elements Links Developmental Processes and Tumorigenesis Save
- PAX gene expression in autosomal dominant polycystic kidney disease contributes to cyst expansion and regulates a gene network associated with cyst growth Save
- Special Issue “Melanoma: From Molecular Pathology to Therapeutic Approaches” Save
- Genomic and Epigenomic Biomarkers of Immune Checkpoint Immunotherapy Response in Melanoma: Current and Future Perspectives Save
- The Role of the PAX Genes in Renal Cell Carcinoma Save
- Peroxidasin is associated with a mesenchymal-like transcriptional phenotype and promotes invasion in metastatic melanoma Save
- Targeted DNA Methylation Editing Using an All-in-One System Establishes Paradoxical Activation of EBF3 Save
- DNA Methylome and Transcriptome Maps of Primary Colorectal Cancer and Matched Liver Metastasis Save
- Co-Expression of Multiple PAX Genes in Renal Cell Carcinoma (RCC) and Correlation of High PAX Expression with Favorable Clinical Outcome in RCC Patients Save
- Phenotype Switching and the Melanoma Microenvironment; Impact on Immunotherapy and Drug Resistance Save
- Dynamic ctDNA mutational complexity in melanoma patients receiving immunotherapy Save
- Assessment of a Size-Based Method for Enriching Circulating Tumour Cells in Colorectal Cancer Save
- Repurposing Melanoma Chemotherapy to Activate Inflammasomes in the Treatment of BRAF/MAPK Inhibitor Resistant Melanoma Save
- Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease Save
- Locus-Specific DNA Methylation Editing in Melanoma Cell Lines Using a CRISPR-Based System Save
- Locus-Specific DNA Methylation Editing in Mammalian Cells using a CRISPR-Based System Save
- Genetic and Genomic Pathways of Melanoma Development, Invasion and Metastasis Save
- Repurposing melanoma chemotherapy to activate inflammasomes in treatment of BRAF/MAPK inhibitor resistant melanoma Save
- Transcriptional Reprogramming and Constitutive PD-L1 Expression in Melanoma Are Associated with Dedifferentiation and Activation of Interferon and Tumour Necrosis Factor Signalling Pathways Save