Jim Smith

About

Jim Smith (MB ChB, BMedSc(Hons)) is a clinician-researcher based in Dunedin, Aotearoa New Zealand. He currently works as a Registrar in General Surgery and Urology at Dunedin Hospital and holds an honorary Research Fellow position within the Department of Pathology and Molecular Medicine, University of Otago. He has expertise in CRISPR-based epigenomic editing, cancer epigenetics, and multi-omic profiling in prostate and pancreatic cancers.

Employment

• Southern District Health Board Registrar
  2024 - Present
• University of Otago Professional Practice Fellow
  2023 - 2023
• University of Otago Honorary Research Fellow
  2022 - Present
• Southern District Health Board House Officer
  2022 - 2024

Education

• University of Otago BMedSc(Hons)
  2018 - 2018
• University of Otago MB ChB
  2015 - 2021

Projects & Funding

Projects & funding information is unavailable.

Publications (16)

• Towards implementation of precision medicine biomarkers in early detection and prognostication of prostate cancer
  Angela Yee, Jim Smith, Rajiv Kumar +3 more
  Cancer and Metastasis Reviews 2026 DOI: 10.1007/s10555-026-10357-8
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• Clinical epigenetics: recent advances and opportunities
  Epigenetics Communications 2025 DOI: 10.1186/s43682-025-00038-y
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• Genome-Scale DNA Methylome and Transcriptome Profiles of Prostate Cancer Recurrence After Prostatectomy
  Jim Smith, Priyadarshana Ajithkumar, Emma J. Wilkinson +9 more
  Data 2024 DOI: 10.3390/data9120150
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• Targeted DNA Methylation Editing Using an All-in-One System Establishes Paradoxical Activation of EBF3
  Rakesh Banerjee, Priyadarshana Ajithkumar, Nicholas Keestra +7 more
  Cancers 2024 DOI: 10.3390/cancers16050898
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• Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications
  International Review of Cell and Molecular Biology 2024 DOI: 10.1016/bs.ircmb.2023.06.002
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• Neuroendocrine Neoplasms
  PET Clinics 2023 DOI: 10.1016/j.cpet.2022.11.003
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• Creating opportunities to improve detection of older adult abuse: a national interRAI study
  BMC Geriatrics 2022 DOI: 10.1186/s12877-022-02938-3
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• Impact of the 2020 New Zealand COVID‐19 lockdown on participants in a community‐based, peer‐led fall prevention program
  Australasian Journal on Ageing 2022 DOI: 10.1111/ajag.13040
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• Bacille Calmette–Guérin vaccination site abscess: When is it a problem?
  Journal of Paediatrics and Child Health 2022 DOI: 10.1111/jpc.15635
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• Epigenetic basis and targeting of cancer metastasis
  Rakesh Banerjee, Jim Smith, Michael Roger Eccles +2 more
  Trends in Cancer 2022 DOI: 10.1016/j.trecan.2021.11.008
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• Editing of DNA Methylation Patterns Using CRISPR-Based Tools
  Methods in Molecular Biology 2022 DOI: 10.1007/978-1-0716-2140-0_4
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• Next-Generation Bisulfite Sequencing for Targeted DNA Methylation Analysis
  Methods in Molecular Biology 2022 DOI: 10.1007/978-1-0716-2140-0_3
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• Locus-Specific DNA Methylation Editing in Mammalian Cells using a CRISPR-Based System
  2021 DOI: 10.1101/2021.10.12.463855
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• Locus-Specific DNA Methylation Editing in Melanoma Cell Lines Using a CRISPR-Based System
  Jim Smith, Rakesh Banerjee, Reema Waly +6 more
  Cancers 2021 DOI: 10.3390/cancers13215433
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• Promoter DNA Hypermethylation and Paradoxical Gene Activation
  Jim Smith, Swapnoleena Sen, Robert J. Weeks +2 more
  Trends in Cancer 2020 DOI: 10.1016/j.trecan.2020.02.007
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• Gene-Specific Targeting of DNA Methylation in the Mammalian Genome
  Arthur Urbano, Jim Smith, Robert J. Weeks +1 more
  Cancers 2019 DOI: 10.3390/cancers11101515
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