Ho Sup Yoon

About

Ho Sup Yoon is an internationally renowned structural and chemical biologist. With BSc from Seoul National University, MSc from Korea Advanced Institute of Science and Technology, and PhD from the University of Chicago, his illustrious career has seen him hold key positions at esteemed institutions. As the President of CHA Advanced Research Institute and Executive Vice President at CHA University, he leads cutting-edge research programs while also serving as a Visiting Professor at Nanyang Technological University, Singapore.

Prof Yoon's pioneering work includes unraveling the PH domain's molecular mechanisms and deciphering the three-dimensional structural portrait of pro-survival Bcl-2 family proteins, contributing to the development of Venetoclax for treating leukemia. His current research spans anti-cell death proteins, immunophilins' roles in diseases, and conformational protein disorders like Parkinson's Disease.

His service record encompasses an array of leadership roles, committee memberships, and editorial contributions. Prof Yoon's impactful publications and dedicated peer review service have enriched the scientific community. Acknowledged with prestigious awards, including the Abbott Drug Discovery Impact Award, he was also honored as the Overseas Korean Scientist of the Year. Elected as a Fellow of The Royal Society of Chemistry, Prof Yoon's valuable contributions continue to shape the fields of structural and chemical biology.

Employment

• CHA University Professor and Executive Vice President (Research)
  2021 - Present
• Nanyang Technological University Professor
  2002 - Present
• Abbott Laboratories Senior Research Scientist
  1993 - 2002

Education

• University of Chicago PhD
  1987 - 1993
• Korea Advanced Institute of Science and Technology MSc
  1982 - 1984
• Seoul National University BSc
  1978 - 1982

Projects & Funding

Projects & funding information is unavailable.

Publications (136)

• Covalent ligands of nuclear receptors
  Sreekanth Rajan, Ho Sup Yoon
  European Journal of Medicinal Chemistry 2023 DOI: 10.1016/j.ejmech.2023.115869
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• Prostaglandin A2 Interacts with Nurr1 and Ameliorates Behavioral Deficits in Parkinson’s Disease Fly Model
  Sreekanth Rajan, Hui Ting Toh, Hong Ye +6 more
  NeuroMolecular Medicine 2022 DOI: 10.1007/s12017-022-08712-3
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• Structural insights into Plasmodium PPIases
  S. S. Rajan, Ho Sup Yoon
  Frontiers in Cellular and Infection Microbiology 2022 DOI: 10.3389/fcimb.2022.931635
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• Antiviral activity against Middle East Respiratory Syndrome coronavirus by Montelukast, an anti-asthma drug
  Gan Hanjie Jonathan, Amaravadhi Harikishore, Jihye Lee +6 more
  Antiviral Research 2021 DOI: 10.1016/j.antiviral.2020.104996
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• PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
  S. S. Rajan, Yongwoo Jang, Chun‐Hyung Kim +22 more
  Nature Chemical Biology 2020 DOI: 10.1038/s41589-020-0553-6
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• Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases
  Scientific Reports 2019 DOI: 10.1038/s41598-019-52085-w
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• Self-powered, on-demand transdermal drug delivery system driven by triboelectric nanogenerator
  Qingling Ouyang, Xueling Feng, Shuangyang Kuang +12 more
  Nano Energy 2019 DOI: 10.1016/j.nanoen.2019.05.056
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• Crystal structure of human vaccinia‐related kinase 1 in complex with AMP‐PNP, a non‐hydrolyzable ATP analog
  Yeen Shian Ngow, S. S. Rajan, Hong Ye +1 more
  Protein Science 2019 DOI: 10.1002/pro.3552
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• Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins
  Journal of Medicinal Chemistry 2018 DOI: 10.1021/acs.jmedchem.8b00137
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• Molecular diversity and function of jasmintides from Jasminum sambac
  Bmc Plant Biology 2018 DOI: 10.1186/s12870-018-1361-y
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• Self-association and conformational variation of NS5A domain 1 of hepatitis C virus
  Journal of General Virology 2018 DOI: 10.1099/jgv.0.001000
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• Biodegradable nanocarriers for small interfering ribonucleic acid (siRNA) co-delivery strategy increase the chemosensitivity of pancreatic cancer cells to gemcitabine
  Chengbin Yang, Kok Ken Chan, Wen-Jen Lin +6 more
  Nano Research 2017 DOI: 10.1007/s12274-017-1521-7
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• Speckle reduction in quantitative phase imaging by generating spatially incoherent laser field at electroactive optical diffusers
  Optics Express 2017 DOI: 10.1364/OE.25.010791
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• Stimuli-responsive multifunctional glyconanoparticle platforms for targeted drug delivery and cancer cell imaging
  Chemical Science 2017 DOI: 10.1039/c6sc05251g
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• Biodegradable charged polyester-based vectors (BCPVs) as an efficient non-viral transfection nanoagent for gene knockdown of the BCR-ABL hybrid oncogene in a human chronic myeloid leukemia cell line
  Chengbin Yang, Nishtha Panwar, Yucheng Wang +9 more
  Nanoscale 2016 DOI: 10.1039/c6nr00996d
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• Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506
  Ajit Prakash, S. S. Rajan, Ho Sup Yoon
  Protein Science 2016 DOI: 10.1002/pro.2875
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• New structural insight of C-terminal region of Syntenin-1, enhancing the molecular dimerization and inhibitory function related on Syndecan-4 signaling
  Scientific Reports 2016 DOI: 10.1038/srep36818
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• Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin
  Ajit Prakash, Joon Su Shin, S. S. Rajan +1 more
  Nucleic Acids Research 2016 DOI: 10.1093/nar/gkw001
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• A Light-Driven Therapy of Pancreatic Adenocarcinoma Using Gold Nanorods-Based Nanocarriers for Co-Delivery of Doxorubicin and siRNA
  Feng Yin, Chengbin Yang, Qianqian Wang +10 more
  Theranostics 2015 DOI: 10.7150/thno.11335
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• Aggregation-induced emission (AIE) dye loaded polymer nanoparticles for gene silencing in pancreatic cancer and their in vitro and in vivo biocompatibility evaluation
  Rui Hu, Chengbin Yang, Yucheng Wang +9 more
  Nano Research 2015 DOI: 10.1007/s12274-014-0642-5
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