Margs Brennan

Employment

• Karolinska Institute Postdoc
  2021 - Present

Education

Education history is unavailable.

Projects & Funding

Projects & funding information is unavailable.

Publications (15)

• Targeting the roots of myeloid malignancies with T cell receptors
  Nature Reviews Cancer 2025 DOI: 10.1038/s41568-025-00857-0
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• Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells.
  Nature immunology 2024 DOI: 10.1038/s41590-024-01845-6
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• A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax.
  Hansen J. Kosasih, Gerry Healey, Margs S. Brennan +14 more
  HemaSphere 2024 DOI: 10.1002/hem3.1
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• Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice.
  Cell death and differentiation 2023 DOI: 10.1038/s41418-023-01250-w
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• Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1.
  Cell death and differentiation 2022 DOI: 10.1038/s41418-022-00946-9
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• Consequences of Zmat3 loss in c-MYC- and mutant KRAS-driven tumorigenesis.
  Cell death & disease 2020 DOI: 10.1038/s41419-020-03066-9
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• MLL-TFE3: a novel and aggressive KMT2A fusion identified in infant leukemia
  Hansen J. Kosasih, N. Davidson, Stefan Bjelosevic +7 more
  Blood Advances 2020 DOI: 10.1182/bloodadvances.2020002708
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• Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use
  Blood 2018 DOI: 10.1182/blood-2018-06-859405
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• Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
  Nature 2018 DOI: 10.1038/s41586-018-0387-5
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• TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1.
  Cell death and differentiation 2018 DOI: 10.1038/s41418-018-0169-5
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• DNA repair processes are critical mediators of p53-dependent tumor suppression.
  Nature medicine 2018 DOI: 10.1038/s41591-018-0043-5
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• Humanized Mcl-1 mice enable accurate pre-clinical evaluation of MCL-1 inhibitors destined for clinical use
  bioRxiv 2018 DOI: 10.1101/335430
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• The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.
  Nature 2016 DOI: 10.1038/nature19830
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• An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo.
  Cell reports 2015 DOI: 10.1016/j.celrep.2015.02.002
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• Characterisation of a novel A1-specific monoclonal antibody.
  Cell death & disease 2014 DOI: 10.1038/cddis.2014.519
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