CM
Conor McCann
UCL, University College London, University of Nevada, Reno, Queen's University Belfast
Research areas: Medicine · Surgery · Congenital gastrointestinal and neural anomalies · Gastrointestinal motility and disorders · Tissue Engineering and Regenerative Medicine
0000-0002-9324-5984
Employment
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UCL Associate Professor2025 - Present
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University College London Lecturer (Regenerative Medicine)2023 - 2025
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UCL Principal investigator2021 - 2023
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UCL Senior Research Fellow2017 - 2020
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University College London Post Doctoral Fellow2011 - 2017
Education
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University of Nevada Reno Ph.D. Cellular and Molecular Pharmacology and Physiology2005 - 2010
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Queens University Belfast BSc. Biomedical Science2001 - 2005
Projects & Funding
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Development of a human pluripotent stem cell-based therapy against Hirschsprung disease Medical Research Council2026 - 2029
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Supporting Health And Research For Everyone Living With Hirschsprung Disease Through Data (SHARE HD) National Institute for Health and Care Research2026 - 2028
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Human enteric nervous system progenitor dynamics during development and disease Medical Research Council2024 - 2027
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Developing a human pluripotent stem cell-based strategy for treating Hirschsprung disease Medical Research Council2021 - 2024
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Using ex vivo organotypic cultures to investigate donor cell integration in the gut National Centre for the Replacement Refinement and Reduction of Animals in Research2021 - 2023
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Understanding how nNOS signaling in the gut influences the development, maintenance and function of interstitial cells of Cajal. Wellcome Trust Ltd2018 - 2021
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Enteric neural stem cell therapy for Oesophageal Achalasia and Diabetic Gastroparesis Guts UK2017 - 2020
Publications (40)
- In Vitro and In Ovo CAM Model Evaluation of Periosteum-Derived Micrografts Save
- Childhood outcomes in children with Hirschsprung disease: a population-based data linkage study in England Save
- Functional and molecular rescue of aganglionic colon by human enteric nervous system progenitor transplantation in Hirschsprung disease Save
- Characterisation and sensory evaluation of placebo OrPhylloTM orodispersible films as a versatile paediatric drug delivery platform. Save
- Engrafted nitrergic neurons derived from hPSCs improve gut dysmotility in mice. Save
- Purinergic signalling and calcium dynamics: potential drivers in the onset of coordinated intestinal motility in human fetal development Save
- A humanized neuronal model system reveals key roles for manganese in neuronal endocytosis, calcium flux and mitochondrial bioenergetics Save
- Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue. Save
- Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy Save
- Synchronisation of apical constriction and cell cycle progression is a conserved behaviour of pseudostratified neuroepithelia informed by their tissue geometry. Save
- Multiple Roles of Ret Signalling During Enteric Neurogenesis. Save
- Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale Save
- Automated computational analysis reveals structural changes in the enteric nervous system of nNOS deficient mice. Save
- Dynamic integration of enteric neural stem cells in ex vivo organotypic colon cultures. Save
- TALPID3/KIAA0586 regulates multiple aspects of neuromuscular patterning during gastrointestinal development in animal models and human Save
- Combined treatment with enteric neural stem cells and chondroitinase ABC reduces spinal cord lesion pathology. Save
- In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution. Save
- Retinoic Acid Accelerates the Specification of Enteric Neural Progenitors from In-Vitro-Derived Neural Crest. Save
- Bioengineered airway epithelial grafts with mucociliary function based on collagen IV- and laminin-containing extracellular matrix scaffolds Save
- Stem Cell Therapy for Enteric Neuropathies Save