Clara Tang
University of Hong Kong, QIMR Berghofer Medical Research Institute
Research areas: Biochemistry, Genetics and Molecular Biology · Genetics · Genetic Associations and Epidemiology · Genomics and Rare Diseases · Congenital gastrointestinal and neural anomalies
0000-0003-0265-2638
About
Dr Clara Sze-Man Tang obtained her PhD in statistical genetics from the University of Hong Kong in 2010 and received her postdoctoral training in asthma genetics and bioinformatics at the QIMR Berghofer Medical Research Institute, previously known as Queensland Institute of Medical Research (QIMR). She is currently a Research Assistant Professor at Department of Surgery of the University of Hong Kong.
Her research interest is on elucidating the genetic basis of complex diseases, including cardiovascular diseases and congenital disorders, such as Hirschsprung disease (HSCR) and congenital heart diseases. Through genome-wide association and copy number analyses, Dr Tang and colleagues successfully identified novel common and rare genetic variants predisposing to HSCR, blood lipid levels (important risk factors for coronary artery disease) and other congenital disorders. She is currently focusing on identifying family-segregating and/or rare genetic variants with potentially large effects using the next-generation sequencing (NGS) approaches.
Employment
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The University of Hong Kong Assistant Professor2020 - Present
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University of Hong Kong Research Assistant Professor2015 - Present
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University of Hong Kong Postdoctoral Fellow2012 - 2015
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QIMR Berghofer Medical Research Institute Research Officer2010 - 2012
Education
- 2007 - 2010
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University of Hong Kong MPhil2004 - 2006
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University of Hong Kong BSc(Bioinformatics)2001 - 2004
Projects & Funding
Projects & funding information is unavailable.
Publications (63)
- HCMV infection disrupts barrier functions and promotes epithelial–mesenchymal transition in a cholangiocyte organoid model Save
- iRUNNER: A Baseline Mutation Burden Regression for Identifying Gene Interaction Between Rare Variants for Diseases Save
- Multifaceted analysis of noncoding and coding de novo variants implicates NOTCH signaling pathway in tetralogy of Fallot in Chinese population Save
- Human Liver Organoids to Predict the Outcome of Kasai Portoenterostomy Save
- Genetics of biliary atresia: Approaches, pathological insights and challenges Save
- Biliary atresia Save
- Isogenic Human-Induced Pluripotent Stem-Cell-Derived Cardiomyocytes Reveal Activation of Wnt Signaling Pathways Underlying Intrinsic Cardiac Abnormalities in Rett Syndrome Save
- Current Understanding in the Clinical Characteristics and Molecular Mechanisms in Different Subtypes of Biliary Atresia Save
- Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors Save
- Roles of Enteric Neural Stem Cell Niche and Enteric Nervous System Development in Hirschsprung Disease Save
- Identification of a wide spectrum of ciliary gene mutations in nonsyndromic biliary atresia patients implicates ciliary dysfunction as a novel disease mechanism Save
- Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development Save
- Actionable pharmacogenetic variants in Hong Kong Chinese exome sequencing data and projected prescription impact in the Hong Kong population. Save
- Identification of a Wide Spectrum of Ciliary Gene Mutations in Nonsyndromic Biliary Atresia Patients Implicates Ciliary Dysfunction as a Novel Disease Mechanism Save
- Actionable secondary findings in 1116 Hong Kong Chinese based on exome sequencing data. Save
- A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease. Save
- Whole-genome analysis of noncoding genetic variations identifies multiscale regulatory element perturbations associated with Hirschsprung disease. Save
- High-sensitivity troponin I and B-type natriuretic peptide biomarkers for prediction of cardiovascular events in patients with coronary artery disease with and without diabetes mellitus. Save
- Cancer gene mutations in congenital pulmonary airway malformation patients. Save
- Identification of Genes Associated With Hirschsprung Disease, Based on Whole-Genome Sequence Analysis, and Potential Effects on Enteric Nervous System Development Save