Dr. Saurabh Gautam

Employment

• Novartis Senior Tech Transfer Lead
  2023 - Present
• Boehringer Ingelheim / ViraTherapeutics GmbH Lab Head
  2020 - 2023
• Max Planck Institute of Biochemistry Marie-Curie Postdoctoral Fellow
  2016 - 2020
• Indian Institute of Technology Delhi Research Scholar (Doctoral)
  2010 - 2016

Education

Education history is unavailable.

Projects & Funding

• Identifying and deciphering the mechanism of the cellular machinery responsible for disaggregation of intracellular prion-like Tau aggregates European Commission
  2017 - 2019

Publications (28)

• The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
  Nature Communications 2023 DOI: 10.1038/s41467-023-36058-2
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• Single-step rapid chromatographic purification and characterization of clinical stage oncolytic VSV-GP
  Frontiers in Bioengineering and Biotechnology 2022 DOI: 10.3389/fbioe.2022.992069
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• The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends
  Nature Communications 2021 DOI: 10.1038/s41467-021-25966-w
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• The Hsc70 Disaggregation Machinery Removes Monomer Units Directly from α-Synuclein Fibril Ends
  bioRxiv 2020 DOI: 10.1101/2020.11.02.365825
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• Exploring the potency of the naturally occurring polyphenol curcumin as a probe for protein aggregation in crowded environments
  Sandip Karmakar, Saikat Chakraborty, Saurabh Gautam +1 more
  International Journal of Biological Macromolecules 2019 DOI: 10.1016/j.ijbiomac.2019.09.049
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• Solid state fluorescence of proteins in high throughput mode and its applications.
  F1000Research 2019 DOI: 10.12688/f1000research.2-82.v2
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• Role of Tryptophan in Protein-Nanocrystals Interaction: Energy or Charge Transfer
  Mona Mittal, Saurabh Gautam, Pramit Kumar Chowdhury +2 more
  Zeitschrift fur Physikalische Chemie 2019 DOI: 10.1515/zpch-2017-1088
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• Structural characterization of a novel KH-domain containing plant chloroplast endonuclease.
  Ashok K. Rout, Himanshu Singh, Sunita Patel

  +5 more

  • Vandana Raghavan
  • Saurabh Gautam
  • Renu Minda
  • Basuthkar Jagadeeshwar Rao
  • Kandala V. R. Chary
  Scientific reports 2018 DOI: 10.1038/s41598-018-31142-w
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• Nanofabrication of myconanoparticles: A future prospect
  Rajender Boddula, Priyanka Dubey, Saurabh Gautam +2 more
  Fungal Nanobionics: Principles and Applications 2018 DOI: 10.1007/978-981-10-8666-3_8
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• Polyphenols in combination with β-cyclodextrin can inhibit and disaggregate α-synuclein amyloids under cell mimicking conditions: A promising therapeutic alternative.
  Saurabh Gautam, Sandip Karmakar, Radhika Batra +5 more
  Biochimica et biophysica acta. Proteins and proteomics 2017 DOI: 10.1016/j.bbapap.2017.02.014
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• Remedial Synergistic Concoction of β-Cyclodextrin and Naturally Occurring Polyphenols Targeting α-Synuclein Aggregation under Cell Mimicking Conditions
  Biophysical Journal 2016 DOI: 10.1016/j.bpj.2015.11.2828
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• Green synthesis of silver nanoparticles using leaf extract of helianthus annuus and mentha longifolia and screening of their antimicrobial activity against escherichia coli
  Nanoscience and Nanotechnology - Asia 2016 DOI: 10.2174/2210681206666160402003808
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• Unusual effects of crowders on heme retention in myoglobin.
  Jayanta Kundu, Uddipan Kar, Saurabh Gautam +2 more
  FEBS letters 2015 DOI: 10.1016/j.febslet.2015.11.015
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• Do Macromolecular Crowding Agents Exert Only an Excluded Volume Effect? A Protein Solvation Study.
  Sanjib Mukherjee, Saurabh Gautam, Saikat Biswas +2 more
  The journal of physical chemistry. B 2015 DOI: 10.1021/acs.jpcb.5b09446
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• β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with α-synuclein.
  Saurabh Gautam, Sandip Karmakar, Abhik Bose +1 more
  Biochemistry 2014 DOI: 10.1021/bi500642f
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• Structure and functional investigation of ligand binding by a family 35 carbohydrate binding module (CtCBM35) of β-mannanase of family 26 glycoside hydrolase from Clostridium thermocellum
  Arabinda Ghosh, Anil Kumar Verma, Saurabh Gautam +2 more
  Biochemistry (Moscow) 2014 DOI: 10.1134/S0006297914070098
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• A novel α-L-arabinofuranosidase of family 43 glycoside hydrolase (Ct43Araf) from Clostridium thermocellum.
  Shadab Ahmed, Ana Sofia Luis, Joana L. A. Brás +5 more
  PloS one 2013 DOI: 10.1371/journal.pone.0073575
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• ANALYSIS OF STRUCTURAL ELEMENT OF FAMILY 6 CARBOHYDRATE BINDING MODULE (CTCBM6B) OF ALPHA-L-ARABINOFURANOSIDASE FROM CLOSTRIDIUM THERMOCELLUM
  Journal of Protein and Proteomics 2013
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• Solid state fluorescence of proteins in high throughput mode and its applications
  2013 DOI: 10.12688/f1000research.2-82.v1
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• Green synthesis of nanocomposites consisting of silver and protease alpha chymotrypsin.
  Ultrasonics sonochemistry 2013 DOI: 10.1016/j.ultsonch.2013.01.004
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