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Tyson V Sharp
Also known as: Tyson Valentine Sharp
Barts Cancer Institute, Barts Health NHS Trust, University of Nottingham
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Cancer Immunotherapy and Biomarkers · Cancer-related Molecular Pathways · RNA Interference and Gene Delivery
0000-0003-1861-7984
About
I obtained my PhD from St. Georges, University of London. After two postdoctoral positions in The Netherlands and USA, I returned to take up a Senior Research Fellow position at the Institute of Cancer Research in London and then UCL. I then moved to the University of Nottingham to set up my independent research group in 2005. From there I relocated to BCI. My group studies the role of the LIM domain family of adaptor proteins and their role in regulating microRNA mediates gene silencing and the hypoxic response and how deregulation of these proteins and pathways contribute to disease states including cancer.
Employment
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Barts Cancer Institute Centre Lead/Head of Department2019 - Present
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Barts Cancer Institute Professor of Cellular and Molecular Biology2018 - Present
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Barts Health NHS Trust Centre Lead (Head of Department)2015 - 2019
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Barts Cancer Institute Reader in Molecular Oncology2013 - 2018
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Barts Cancer Institute Senior Non-Clinical Lecturer in Molecular Oncology2012 - 2018
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University of Nottingham Lecturer in Cell and Molecular Biology2005 - 2011
Education
Education history is unavailable.
Projects & Funding
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Defining CoAsy as a new breast cancer tumour suppressor Breast Cancer Now2023 - 2026
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A confocal microscope for multidisciplinary dynamic studies of complex biological systems Biotechnology and Biological Sciences Research Council2022 - 2023
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The Lexicon of miRISC: Deconstructing the functional complexity of the miRNA induced silencing complex Biotechnology and Biological Sciences Research Council2021 - 2024
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Super-Resolution Microscopy of live cells in 3D Biotechnology and Biological Sciences Research Council2020 - 2021
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Discovering new RNA biology in lung cancer Biotechnology and Biological Sciences Research Council2020 - 2024
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Unravelling the Mechanism of the Lung Tumour Suppressor LIMD1 from Cellular Metabolism to Malignant Transformation. Medical Research Council2016 - 2019
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Characterisation of a new mechanism of regulation for HIF1 and the hypoxic response. Biotechnology and Biological Sciences Research Council2014 - 2017
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Taiwan and UK International Partnership towards the advancement and discovery of novel microRNA species and regulatory proteins in stem cell biology. Biotechnology and Biological Sciences Research Council2013 - 2015
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Pre-commercialisation validation of Stem Cell Generator as a highly efficient single transfection iPSC reprogramming vector Biotechnology and Biological Sciences Research Council2012 - 2013
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Investigating the role of LIMD1 loss in the aetiology of lung cancer stem cells Cancer Research UK2012 - 2015
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The new LAW of microRNA-mediated gene silencing Biotechnology and Biological Sciences Research Council2012 - 2015
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Investigating the role of LIMD1 loss in the aetiology of lung cancer stem cells Cancer Research UK2012 - 2015
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The new LAW of microRNA-mediated gene silencing Biotechnology and Biological Sciences Research Council2011 - 2011
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Spatio-temporal structural and functional studies into the novel interaction between LIMD1 and clathrin heavy chain proteins Biotechnology and Biological Sciences Research Council2008 - 2011
Publications (56)
- The AGO2 adaptor LIMD1 expands the functional and evolutionary reach of microRNA targeting Save
- C-terminal tagging impairs AGO2 function Save
- An AGO2 adaptor expands the functional and evolutionary reach of microRNA targeting Save
- The DNA mismatch repair protein, MSH6 is a novel regulator of PD-L1 expression Save
- LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung Cancer Save
- LIMD1 Loss as an Early Driver of PD-L1 Upregulation and Immune Evasion in Lung Cancer Save
- The DNA Mismatch repair protein, MSH6 is a novel regulator of PD-L1 expression Save
- STAG3 promotes exit from pluripotency through post-transcriptional mRNA regulation in the cytoplasm Save
- STAG3 promotes exit from pluripotency through post-transcriptional mRNA regulation in the cytoplasm Save
- C-terminal tagging impairs AGO2 function Save
- Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes Save
- Oncometabolite induced primary cilia loss in pheochromocytoma Save
- miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity Save
- A HIF–LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia Save
- Deregulation of LIMD1–VHL–HIF-1α–VEGF pathway is associated with different stages of cervical cancer Save
- LIMD1 is induced by and required for LMP1 signaling, and protects EBV-transformed cells from DNA damage-induced cell death Save
- Ajmaline blocks I<inf>Na</inf> and I<inf>Kr</inf> without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters Save
- Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins Save
- MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells Save
- Over expression of HIF1α is associated with inactivation of both LimD1 and VHL in renal cell carcinoma: Clinical importance Save