Giacomo Milletti

Employment

• Università Cattolica del Sacro Cuore Assistant Professor (RTT)
  2026 - Present
• Danish Cancer Society Post-doctoral Fellow
  2022 - Present
• Ospedale Pediatrico Bambino Gesù Post-doctoral Fellow
  2022 - 2022
• Ospedale Pediatrico Bambino Gesù PhD student
  2017 - 2022

Education

• Sapienza University of Rome Master Dergee's in Neurobiology
  2016 - 2018
• University of Strasbourg Erasmus Student
  2014 - 2015
• University of Rome Tor Vergata Bachelor in Biology
  2013 - 2016

Projects & Funding

Projects & funding information is unavailable.

Publications (14)

• Iron-deficiency activates the GABARAP-FLCN/FNIP1-TFEB axis to promote pexophagy
  2026 DOI: 10.1083/jcb.202411213
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• Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress
  Nucleic Acids Research 2026 DOI: 10.1093/nar/gkag595
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• Stepwise DNA damage and repair mechanisms at replication forks in response to topoisomerase I inhibition
  DNA Repair 2026 DOI: 10.1016/j.dnarep.2025.103914
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• The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis
  Science Advances 2025 DOI: 10.1126/sciadv.adw7376
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• NAD+ regulates nucleotide metabolism and genomic DNA replication
  Nature Cell Biology 2023 DOI: 10.1038/s41556-023-01280-z
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• AMBRA1 phosphorylation by CDK1 and PLK1 regulates mitotic spindle orientation
  2023 DOI: 10.1007/s00018-023-04878-6
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• Cyclers' kinases in cell division: from molecules to cancer therapy
  2023 DOI: 10.1038/s41418-023-01196-z
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• Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling
  Acta Neuropathologica 2021 DOI: 10.1007/s00401-021-02347-7
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• TFG binds LC3C to regulate ULK1 localization and autophagosome formation
  Marianna Carinci, Beatrice Testa, Matteo Bordi

  +26 more

  • Giacomo Milletti
  • Massimo Bonora
  • Laura Antonucci
  • Caterina Ferraina
  • Marta Carro-Alvarellos
  • +21 more
  The EMBO Journal 2021 DOI: 10.15252/embj.2019103563
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• CRL4AMBRA1 is a master regulator of D-type cyclins
  Nature 2021 DOI: 10.1038/s41586-021-03445-y
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• AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity
  Emiliano Maiani, Giacomo Milletti, Francesca Nazio +43 more
  2021 DOI: 10.1038/s41586-021-03422-5
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• Recent advances in understanding the role of autophagy in paediatric brain tumours
  2021 DOI: 10.3390/diagnostics11030481
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• The pro-autophagic protein AMBRA1 coordinates cell cycle progression by regulating CCND (cyclin D) stability
  2021 DOI: 10.1080/15548627.2021.1985917
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• Canonical and noncanonical roles of fanconi anemia proteins: Implications in cancer predisposition
  2020 DOI: 10.3390/cancers12092684
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