FN
FRANCESCA NAZIO
University of Rome Tor Vergata, Bambino Gesù Children's Hospital, Università degli Studi di Roma Tor Vergata Dipartimento di Biologia
Research areas: Biochemistry, Genetics and Molecular Biology · Cell Biology · Autophagy in Disease and Therapy · Glioma Diagnosis and Treatment · CAR-T cell therapy research
0000-0002-3039-4448
Employment
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University of Rome Tor Vergata Associate Professor2025 - Present
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University of Rome Tor Vergata Ricercatore (RtdB)2022 - 2025
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Ospedale Pediatrico Bambino Gesù Researcher2016 - 2022
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Universita degli Studi di Roma Tor Vergata Post Doc Researcher2015 - 2016
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Fondazione Santa Lucia Istituto di Ricovero e Cura a Carattere Scientifico Post Doc Researcher2011 - 2015
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University of Tor Vergata Filas SPA fellowship for gratuated student2008 - 2008
Education
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Università degli Studi di Roma Tor Vergata Dipartimento di Biologia PhD in Cellular and Molecular Biology2008 - 2011
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Università degli Studi di Roma Tor Vergata Dipartimento di Biologia Master Degree in Cellular and Molecular Biology2006 - 2007
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Università degli Studi di Roma Tor Vergata Dipartimento di Biologia First level degree2002 - 2005
Projects & Funding
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Reprogramming the Tumor Immune Landscape: Combined Use of NK Cells and Radiotherapy in High- Risk Medulloblastoma Cure Starts Now Foundation2026 - 2026
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Mitochondrial Dysregulation as a Prognostic Factor and Therapeutic Target in Medulloblastoma Mia Neri Foudation2025 - 2026
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Unravelling new strategies for boosting Natural Killer cell-mediated targeting of medulloblastoma Fondazione Roche per la Ricerca Indipendente2024 - 2025
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Dissecting the role of mitochondria in medulloblastoma stem cells dissemination and radiotherapy resistance AIRC2023 - 2027
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Targeting autophagy to boost the immune response against medulloblastoma CureSearch for Children Cancer2022 - 2024
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Autophagy manipulation as a novel strategy for stimulating the immune response in neuroblastoma Ministero della Salute2020 - 2025
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"Identification of new molecular targets promoting bone-marrow pre-metastatic niche in neuroblastoma" Italian Ministry of health2018 - 2021
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Project Title: Cell autophagy modulation via energy balance regulation: age-dependent outcomes on inflammation, axon regeneration and neuropathic pain in murine models of peripheral nerve lesion Ministero della Salute2015 - 2017
Publications (59)
- HnRNP C binding to inverted Alu elements protects the transcriptome from pre-mRNA circularization Save
- Proteasome inhibition promotes Foxn1 expression in thymic epithelial cells and induces thymic regeneration in mice Save
- Medulloblastoma: Molecular Targets and Innovative Theranostic Approaches Save
- Inhibition of autophagy enhances the antitumor efficacy of T/CAR T cell against neuroblastoma Save
- Unveiling the peripheral nerve hallmarks of chemotherapy-induced neuropathy: insights from paclitaxel treatment in a murine model Save
- GD2-Targeting CAR T-cell Therapy for Patients with GD2+ Medulloblastoma Save
- Genome-wide DNA methylation profiling in Fanconi anemia identifies a robust signature for the clinical classification of VUS in FANC genes and reverted patients Save
- Mitochondrial Transfer as a Strategy for Enhancing Cancer Cell Fitness: Current Insights and Future Directions Save
- Trimetazidine Improves Mitochondrial Dysfunction in SOD1G93A Cellular Models of Amyotrophic Lateral Sclerosis through Autophagy Activation Save
- Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies Save
- Identification of a robust DNA methylation signature for Fanconi anemia Save
- MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma Save
- Should I stay or should I go? Spatio-temporal control of cellular anchorage by hematopoietic factors orchestrates tumor metastatic cascade Save
- Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction Save
- Pathological implications of metabolic reprogramming and its therapeutic potential in medulloblastoma Save
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Save
- AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity Save
- CRL4AMBRA1 is a master regulator of D-type cyclins Save
- Recent Advances in Understanding the Role of Autophagy in Paediatric Brain Tumours Save
- TFG binds LC3C to regulate ULK1 localization and autophagosome formation Save