NC
Naresh Chennamsetty
Bristol-Myers Squibb, Massachusetts Institute of Technology, North Carolina State University
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Protein purification and stability · Monoclonal and Polyclonal Antibodies Research · Protein Structure and Dynamics
0000-0003-4641-7840
Employment
-
Bristol-Myers Squibb Associate Scientific Director
Education
- 2006 - 2009
- 2000 - 2005
Projects & Funding
Projects & funding information is unavailable.
Publications (37)
- Characterizing and understanding the formation of cysteine conjugates and other by-products in a random, lysine-linked antibody drug conjugate Save
- Size exclusion chromatography for the characterization and quality control of biologics Save
- Impact of virus-antibody interactions on viral clearance in anion exchange chromatography Save
- Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb Save
- Cyclization of N-Terminal Glutamic Acid to pyro-Glutamic Acid Impacts Monoclonal Antibody Charge Heterogeneity Despite Its Appearance as a Neutral Transformation Save
- Probing the Tryptophan Environment in Therapeutic Proteins: Implications for Higher Order Structure on Tryptophan Oxidation Save
- Quadrupole Dalton-Based Controlled Proteolysis Method for Characterization of Higher Order Protein Structure Save
- Streamlining the polishing step development process via physicochemical characterization of monoclonal antibody aggregates Save
- Enhanced Precision of Circular Dichroism Spectral Measurements Permits Detection of Subtle Higher Order Structural Changes in Therapeutic Proteins Save
- Purity Determination by Capillary Electrophoresis Sodium Hexadecyl Sulfate (CE-SHS): A Novel Application for Therapeutic Protein Characterization Save
- Insights in understanding aggregate formation and dissociation in cation exchange chromatography for a structurally unstable Fc-fusion protein Save
- Modeling the Oxidation of Methionine Residues by Peroxides in Proteins Save
- Understanding, predicting, and mitigating the impact of post-translational physicochemical modifications, including aggregation, on the stability of biopharmaceutical drug products Save
- An Introduction to Coarse-Graining Approaches: Linking Atomistic and Mesoscales Save
- A screening tool for therapeutic monoclonal antibodies: Identifying the most stable protein and its best formulation based on thioflavin T binding Save
- Developability index: A rapid in silico tool for the screening of antibody aggregation propensity Save
- An Introduction to Coarse-Graining Approaches: Linking Atomistic and Mesoscales Save
- Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and thioflavin T binding Save
- Determining solubility of APIs and intermediates from automated parallel experiments and modeling Save
- Evaluation of a non-arrhenius model for therapeutic monoclonal antibody aggregation Save