MG
Melanie Grandits
Accord Healthcare, King's College London, St George's, University of London, TU Wien, Epsilogen Ltd/King's College London
Research areas: Medicine · Oncology · Monoclonal and Polyclonal Antibodies Research · Cancer Immunotherapy and Biomarkers · HER2/EGFR in Cancer Research
0000-0001-8143-8298
Employment
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Accord Healthcare Bioanalytical Research Scientist2025 - Present
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King's College London Visiting Postdoctoral Research Associate2025 - Present
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Epsilogen Ltd/King's College London Postdoctoral Research Associate2020 - 2024
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Vienna University of Technology Research Assistant2015 - 2015
Education
- 2016 - 2021
- 2012 - 2015
- 2008 - 2012
Projects & Funding
Projects & funding information is unavailable.
Publications (19)
- Hybrid IgE-IgG1 antibodies (IgEG): a new antibody class that combines IgE and IgG functionality Save
- Tuning antibody stability and function by rational designs of framework mutations Save
- An Fc-Engineered Glycomodified Antibody Supports Proinflammatory Activation of Immune Effector Cells and Restricts Progression of Breast Cancer Save
- Hyperinflammatory repolarisation of ovarian cancer patient macrophages by anti-tumour IgE antibody, MOv18, restricts an immunosuppressive macrophage:Treg cell interaction Save
- Tuning antibody stability and function by rational designs of framework mutations Save
- Fc-mediated immune stimulating, pro-inflammatory and antitumor effects of anti-HER2 IgE against HER2-expressing and trastuzumab-resistant tumors Save
- An IgE antibody targeting HER2 identified by clonal selection restricts breast cancer growth via immune-stimulating activities Save
- Physiochemical and functional evaluation of the first-in-class anti-cancer IgE antibody drug, MOv18, through process development and good manufacturing practice production Save
- Anti‐PD1 therapy outcome can be predicted by pre‐therapy IFN‐I responsiveness of Teff cells Save
- Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4 Save
- Improving the efficacy of plant-made anti-HIV monoclonal antibodies for clinical use Save
- Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes Save
- Generation and Characterization of Native and Sialic Acid-Deficient IgE Save
- Engineering the N-glycosylation pathway of Nicotiana tabacum for molecular pharming using CRISPR/Cas9 Save
- Clinical and Translational Significance of Basophils in Patients with Cancer Save
- Insights from IgE Immune Surveillance in Allergy and Cancer for Anti-Tumour IgE Treatments Save
- Characterisation of a highly potent and near pan-neutralising anti-HIV monoclonal antibody expressed in tobacco plants Save
- Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2 Save
- Engineering the interactions between a plant‐produced HIV antibody and human Fc receptors Save