Nan Zhang

Employment

• Synerk Biotech Senior Director
  2022 - Present
• Houston Methodist Academic Institute Research Scientist
  2018 - 2022
• Weill Cornell Medicine Assistant Research Professor
  2018 - 2022
• Houston Methodist Research Institute Research Associate
  2016 - 2018
• Imperial College London Research Associate
  2011 - 2016

Education

Education history is unavailable.

Projects & Funding

• A DNAzyme that targets the CAG repeat RNA in polyglutamine diseases National Ataxia Foundation
  2020 - 2021
• DNAzymes for COVID-19 Houston Methodist Research Institute
  2020 - 2021
• A CRISPR-C2c2 based system to target toxic RNA in myotonic dystrophy type 1 AFM-Telethon
• A CRISPR-Cas13a based system to target toxic RNA in myotonic dystrophy type 1 National Institute of Neurological Disorders and Stroke

Publications (41)

• Exploring environmental exposomes and the gut-brain nexus: Unveiling the impact of pesticide exposure
  Shing Ching Khoo, Nan Zhang, Vijitra Luang‐In +3 more
  Environmental Research 2024 DOI: 10.1016/j.envres.2024.118441
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• Use, exposure and omics characterisation of potential hazard in nanomaterials
  Nyuk Ling, Nan Zhang, Wilson Thau Lym Yong

  +6 more

  • Suzana Misbah
  • Fatimah Hashim
  • Chin Fhong Soon
  • Gim Pao Lim
  • Wanxi Peng
  • +1 more
  Materials Today Advances 2023 DOI: 10.1016/j.mtadv.2023.100341
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• The RNA repair proteins RtcAB regulate transcription activator RtcR via its CRISPR-associated Rossmann fold domain
  iScience 2022 DOI: 10.1016/j.isci.2022.105425
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• Editorial: Neurodegeneration: From Disease Mechanism to Therapeutic Advancement
  Frontiers in Genetics 2022 DOI: 10.3389/fgene.2022.941846
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• Mechanistic and Therapeutic Insights into Ataxic Disorders with Pentanucleotide Expansions
  Cells 2022 DOI: 10.3390/cells11091567
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• Polyglutamine Expansion in Huntingtin and Mechanism of DNA Damage Repair Defects in Huntington’s Disease
  Frontiers in Cellular Neuroscience 2022 DOI: 10.3389/fncel.2022.837576
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• DNAzyme as a rising gene-silencing agent in theranostic settings
  Neural Regeneration Research 2022 DOI: 10.4103/1673-5374.335157
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• DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases
  Neurotherapeutics 2021 DOI: 10.1007/s13311-021-01075-w
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• Neurological impacts of COVID-19
  J Clin Neurol Neurosurg 2021
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• RNA-mediated metabolic defects in microsatellite expansion diseases
  RNA Damage and Repair 2021
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• A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1
  Frontiers in Genetics 2020 DOI: 10.3389/fgene.2020.594576
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• A CRISPR-associated Rossmann fold (CARF) domain regulates transcription of an RNA repair system in Escherichia coli
  Access Microbiology 2019 DOI: 10.1099/acmi.ac2019.po0509
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• Intravenously Administered Novel Liposomes, DCL64, Deliver Oligonucleotides to Cerebellar Purkinje Cells
  The Cerebellum 2018
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• A CRISPR- C2c2 system to track and eliminate toxic RNA in Myotonic Dystrophy Type 1
  Myotonic Dystrophy Type 1 Symposium 2018
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• A CRISPR-C2c2 based system to target toxic RNA in Myotonic Dystrophy type 1
  American Society of Human Genetics Annual Meeting 2017
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• A CRISPR-C2c2 based system to target toxic RNA in Myotonic Dystrophy type 1
  International Myotonic Dystrophy Consortium Meeting 11 2017
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• Mutant polyglutamine proteins impair transcription-coupled DNA repair to trigger neurotoxicity in CAG repeat expansion diseases
  Gordon Conference: CAG Triplet Repeat Disorders 2017
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• RNA toxicity and foci formation in microsatellite expansion diseases
  Current opinion in genetics & development 2017 DOI: https://doi.org/10.1016/j.gde.2017.01.005
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• Structures of RNA Polymerase Closed and Intermediate Complexes Reveal Mechanisms of DNA Opening and Transcription Initiation
  Molecular Cell 2017
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• The bacterial enhancer-dependent RNA polymerase
  Biochemical Journal 2016
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