Dr. Prabakaran D.S
Research areas: Pharmacology, Toxicology and Pharmaceutics · Pharmaceutical Science · Advanced Drug Delivery Systems · Drug Solubulity and Delivery Systems · Molecular Sensors and Ion Detection
0000-0002-2486-5290
About
We have been investigating the role of Fused Toes Homolog (FTS) and its central role in cervical carcinogenesis. Radiation/cisplatin-induced activation of Epidermal growth factor receptor (EGFR) and Notch signaling confers chemo and radio resistance. we identified that FTS is involved in conferring radio- resistance. we identified the regulation of EGFR nuclear Phosphorylation and Notch mediated cancer stem cell activation by FTS upon radiation (x-ray and Carbon ion). Further, silencing of FTS combined X-ray/C-ion/cisplatin combination targets the EGFR, Notch signaling in cervical cancer cells. Also, FTS silencing reduced the spheroid formation ability and cancer stem cells markers (Oct4A, Sox2, Nanog). More importantly, we identified that silencing of FTS reduced the expression of HPV16 E6 and E7 protein levels via ubiquitin mediated proteasomal degradation, and increased the tumor suppressor protein p53 and Rb in HPV 16 positive CaSki and SiHa cells.
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Publications (28)
- Title: Developing new therapeutic Radio-sensitizers/radio-protectors from marine algae on HPV+ cervical and HNSCC cancers Save
- Exploring Zinc C295 as a Dual HIV-1 Integrase Inhibitor: From Strand Transfer to 3′-Processing Suppression Save
- Correction: Mukherjee et al. Insights into the Scenario of SARS-CoV-2 Infection in Male Reproductive Toxicity. Vaccines 2023, 11, 510 Save
- Exploring salivary gene expression clusters: A bioinformatics approach for advanced diagnosis and prognosis in head and neck squamous cell carcinoma Save
- Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development Save
- Innate Immune Response Assessment in Cyprinus carpio L. upon Experimental Administration with Artemia salina Bio-Encapsulated Aeromonas hydrophila Bacterin Save
- Insights into the Scenario of SARS-CoV-2 Infection in Male Reproductive Toxicity Save
- Molecular Crosstalk between the Immunological Mechanism of the Tumor Microenvironment and Epithelial–Mesenchymal Transition in Oral Cancer Save
- Role of Immune Cells and Receptors in Cancer Treatment: An Immunotherapeutic Approach Save
- The Cellular and Molecular Immunotherapy in Prostate Cancer Save
- Properties of Cellulose Pulp and Polyurethane Composite Films Fabricated with Curcumin by Using NMMO Ionic Liquid Save
- EGFR-Based Targeted Therapy for Colorectal Cancer—Promises and Challenges Save
- Construction of a simple dual-channel fluorescence chemosensor for Cu2+ ion and GSSG detection and its mitochondria-targeting bioimaging applications Save
- Silencing of Fused Toes Homolog (FTS) Increases Radiosensitivity to Carbon-Ion Through Downregulation of Notch Signaling in Cervical Cancer Cells. Save
- Radiobiological Difference between Flattening Filter Free (FFF) Vs. Flattening Filter (FF) X-Ray Beams in Lung Cancer Cells Save
- Modulation of radiosensitivity to C-12 by FTS in cervical cancer cells Save
- Silencing of fused toes homolog (FTS) combined with carbon ion irradiation increases cell killing synergistically through notch mediated signaling in cervical cancer cells Save
- Silencing of FTS increases radiosensitivity by blocking radiation-induced Notch1 activation and spheroid formation in cervical cancer cells Save
- FTS regulates ROS-induced Cu-Zn SOD expression in cervical cancer cells Save
- PO-0982: Fused Toes Homolog (FTS) is a potential target for Notch-mediated radioresistance in cervical cancer Save