Conrad Leonard

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Publications (41)

• Explainable machine learning identifies features and thresholds predictive of immunotherapy response
  2025 DOI: 10.1101/2025.03.23.643560
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• Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) Samples from Advanced Non-Small Cell Lung Cancer for Whole Genome, Whole Exome and Comprehensive Panel Sequencing
  David I. Fielding, Vanessa Lakis, Andrew J. Dalley +28 more
  Cancers 2024 DOI: 10.3390/cancers16040785
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• The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study
  Aimee L. Davidson, Uwe Dressel, Sarah Norris +48 more
  Genome Medicine 2023 DOI: 10.1186/s13073-023-01223-1
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• Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy
  Marjan Mojtabavi Naeini, Felicity Newell, Lauren G. Aoude +37 more
  Nature Communications 2023 DOI: 10.1038/s41467-023-38891-x
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• streammd: fast low-memory duplicate marking using a Bloom filter
  Bioinformatics 2023 DOI: 10.1093/bioinformatics/btad181
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• Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes
  Felicity Newell, Peter A. Johansson, James S. Wilmott +32 more
  Cancer Discovery 2022 DOI: 10.1158/2159-8290.cd-22-0603
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• Analysis of hereditary cancer gene variant classifications from ClinVar indicates a need for regular reassessment of clinical assertions
  Aimee L. Davidson, Olga Kondrashova, Conrad Leonard +7 more
  Human Mutation 2022 DOI: 10.1002/humu.24468
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• Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma
  Jenette Creaney, Ann‐Marie Patch, Venkateswar Addala +27 more
  Genome Medicine 2022 DOI: 10.1186/s13073-022-01060-8
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• Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels
  Priya Ramarao-Milne, Olga Kondrashova, AM Patch +34 more
  ESMO Open 2022 DOI: 10.1016/j.esmoop.2022.100540
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• qmotif: determination of telomere content from whole-genome sequence data
  Bioinformatics Advances 2022 DOI: 10.1093/bioadv/vbac005
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• Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence
  Gastroenterology 2022 DOI: 10.1053/j.gastro.2021.09.022
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• Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance
  Felicity Newell, Inês Pires da Silva, Peter A. Johansson +25 more
  Cancer Cell 2022 DOI: 10.1016/j.ccell.2021.11.012
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• DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association
  Vanessa Lakis, Rita Teresa Lawlor, Felicity Newell +97 more
  Communications Biology 2021 DOI: 10.1038/s42003-020-01469-0
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• Considerations for using population frequency data in germline variant interpretation: Cancer syndrome genes as a model
  Aimee L. Davidson, Conrad Leonard, Lambros T. Koufariotis +6 more
  Human Mutation 2021 DOI: 10.1002/humu.24183
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• Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
  Stephan B. Dreyer, Rosanna Upstill‐Goddard, Viola Paulus-Hock +97 more
  Gastroenterology 2021 DOI: 10.1053/j.gastro.2020.09.043
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• Using whole-genome sequencing data to derive the homologous recombination deficiency scores
  Xavier Marc De Luca, Felicity Newell, Stephen H. Kazakoff +11 more
  npj Breast Cancer 2020 DOI: 10.1038/s41523-020-0172-0
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• Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours
  Peter A. Johansson, Kelly M. Brooks, Felicity Newell +32 more
  Nature Communications 2020 DOI: 10.1038/s41467-020-16276-8
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• Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity
  Felicity Newell, James S. Wilmott, Peter A. Johansson +32 more
  Nature Communications 2020 DOI: 10.1038/s41467-020-18988-3
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• HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
  Holly Brunton, Giuseppina Caligiuri, Richard Cunningham +97 more
  Cell Reports 2020 DOI: 10.1016/j.celrep.2020.107625
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• Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs
  Biomaterials 2020 DOI: 10.1016/j.biomaterials.2019.119742
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