Florence M. G. Cavalli

Employment

• Institut Curie Junior Group Leader
  2020 - Present
• Hospital for Sick Children Bioinformatics project leader
  2016 - 2020
• Hospital for Sick Children Research Fellow
  2011 - 2016

Education

• University of Cambridge PhD
  2006 - 2011

Projects & Funding

Projects & funding information is unavailable.

Publications (43)

• Cell-type deconvolution methods for spatial transcriptomics
  Nature Reviews Genetics 2025 DOI: 10.1038/s41576-025-00845-y
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• VC-resist glioblastoma cell state: vessel co-option as a key driver of chemoradiation resistance.
  Nature communications 2024 DOI: 10.1038/s41467-024-47985-z
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• CD155 is a putative therapeutic target in medulloblastoma
  Clinical and Translational Oncology 2022 DOI: 10.1007/s12094-022-02975-9
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• Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma
  iScience 2022 DOI: 10.1016/j.isci.2022.105118
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• Failure of human rhombic lip differentiation underlies medulloblastoma formation
  Nature 2022 DOI: 10.1038/s41586-022-05215-w
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• The transcriptional landscape of Shh medulloblastoma
  Patryk Skowron, Hamza Farooq, Florence M.G. Cavalli +96 more
  Nature Communications 2021 DOI: 10.1038/s41467-021-21883-0
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• PRMT5 inhibition disrupts splicing and stemness in glioblastoma
  Nature Communications 2021 DOI: 10.1038/s41467-021-21204-5
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• Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival
  eLife 2021 DOI: 10.7554/elife.64090
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• Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity
  Nature Cancer 2021 DOI: 10.1038/s43018-020-00154-9
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• Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.
  Kulandaimanuvel Antony Michealraj, Sachin A. Kumar, Leo J.Y. Kim +63 more
  Cell 2020 DOI: 10.1016/j.cell.2020.04.047
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• Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
  Laura Donovan, Alberto Delaidelli, Sujith K. Joseph +53 more
  Nature medicine 2020 DOI: 10.1038/s41591-020-0827-2
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• Stalled developmental programs at the root of pediatric brain tumors.
  Selin Jessa, Alexis Blanchet-Cohen, Brian Krug +37 more
  Nature genetics 2019 DOI: 10.1038/s41588-019-0531-7
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• Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma.
  Hiromichi Suzuki, Sachin A. Kumar, Shimin Shuai +65 more
  Nature 2019 DOI: 10.1038/s41586-019-1650-0
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• An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma.
  EMBO molecular medicine 2019 DOI: 10.15252/emmm.201809830
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• High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma.
  Genome research 2019 DOI: 10.1101/gr.246520.118
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• Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
  Cell stem cell 2019 DOI: 10.1016/j.stem.2019.05.013
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• Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma.
  BMC cancer 2019 DOI: 10.1186/s12885-019-5742-x
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• Childhood cerebellar tumours mirror conserved fetal transcriptional programs.
  Maria Claudia Vladoiu, Ibrahim El-Hamamy, Laura Donovan +36 more
  Nature 2019 DOI: 10.1038/s41586-019-1158-7
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• Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.
  Cell reports 2019 DOI: 10.1016/j.celrep.2019.03.047
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• Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma.
  Mary Hoffman, Aaron H. Gillmor, Daniel J. Kunz +28 more
  Cancer research 2019 DOI: 10.1158/0008-5472.can-18-3441
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