KN

Kouta Niizuma

Harvard University, Massachusetts General Hospital, University of Tsukuba, Stanford University

Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Hematopoietic Stem Cell Transplantation · Pluripotent Stem Cells Research · Mesenchymal stem cell research

ORCID iD 0000-0003-1183-1873
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About

My primary research focus is on elucidating the underlying mechanisms of immune system functionality and pioneering technologies to modulate human immune responses. My extensive academic and research background has equipped me with profound expertise in Immunology, Biochemistry, and Stem Cell Biology. Under the mentorship of Professor Akira Shibuya, my early research aimed at dissecting the activation dynamics of innate immune cells, specifically focusing on the CD300/MAIR family receptors. Our research identified the critical role of the mouse Myeloid-associated immunoglobulin-like receptor II (MAIR-II) in bacterial clearance. Translating these findings to human biology led to the identification of CD300H, a novel CD300 family member, and the development of a monoclonal antibody via hybridoma technology. My subsequent research under Professor Lewis L. Lanier involved investigating the NKG2D receptor's role in NK cells during viral infections, enhancing my skills in immunological assays and transplantation models. Currently, under the guidance of Professor Hiromitsu Nakauchi, my research integrates principles of immunology and stem cell biology to develop innovative therapeutic strategies. Significant accomplishments include generating lung cancer neoantigen-specific iPSC-derived T cells, developing monoclonal antibodies for HLA-A, and pioneering scalable macrophage production from Hematopoietic Stem/Progenitor Cells (HSPCs).

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Publications (14)