Jawed Siddiqui
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Cancer Cells and Metastasis · Bone Metabolism and Diseases · Brain Metastases and Treatment
0000-0003-1287-3004
About
Our lab has developed unique techniques and experimental models that allow us to decipher bone metastasis. Metastatic tumors attain the skill to blunt or overturn the functions of the immune system. We are interested in dissecting how metastatic cancers evolve to persuade the immune system dysfunctionality in primary and metastatic sites among tumors of diverse genetic backgrounds. Unraveling the mechanisms of the immune system and bone cell cross-talk offers therapeutic possibilities for bone metastasis. We study how cancer cells influence bone resident macrophages (Osteomacs) for their colonization and growth within the bone microenvironment and design therapeutic strategies accordingly.
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Publications (81)
- Insulin resistance: The central node of convergence between unfolded protein response, diabetes, and cancer. Save
- Nanomedicine in Cancer Therapeutics: Current Perspectives from Bench to Bedside. Save
- Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights. Save
- Editorial: Deciphering the role of signature genes in cancer prognosis and therapy resistance. Save
- Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6. Save
- Oncogenic potential of truncated-Gli3 via the Gsk3β/Gli3/AR-V7 axis in castration-resistant prostate cancer. Save
- Ribosome biogenesis, altered metabolism and ribotoxic stress response in pancreatic ductal adenocarcinoma tumor microenvironment. Save
- A Systematic Review and Meta‐Analysis of the Effects of Dietary Isoflavones on Female Hormone‐Dependent Cancers for Benefit–Risk Evaluation Save
- Clofazimine inhibits small-cell lung cancer progression by modulating the kynurenine/aryl hydrocarbon receptor axis. Save
- Diverse landscape of genetically engineered mouse models: Genomic and molecular insights into prostate cancer Save
- Autophagy as a Therapeutic Target in Breast Tumors: The Cancer stem cell perspective. Save
- Dissecting the MUC5AC/ANXA2 signaling axis: implications for brain metastasis in lung adenocarcinoma. Save
- Racial disparity in prostate cancer: an outlook in genetic and molecular landscape. Save
- Copper metabolism and cuproptosis in human malignancies: Unraveling the complex interplay for therapeutic insights Save
- From orphan to oncogene: The role of GPR35 in cancer and immune modulation. Save
- Hydroxychloroquine interaction with phosphoinositide 3-kinase modulates prostate cancer growth in bone microenvironment: In vitro and molecular dynamics based approach. Save
- α-lipoic acid modulates prostate cancer cell growth and bone cell differentiation Save
- Gum acacia dietary fiber: Significance in immunomodulation, inflammatory diseases, and cancer. Save
- Chemotherapy in pediatric brain tumor and the challenge of the blood–brain barrier Save
- The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations. Save