Shawez Khan
Martin Luther University Halle-Wittenberg, Herlev Hospital National Center for Cancer Immune Therapy, KU Leuven, Université Paris-Saclay, Jawaharlal Nehru University, Jamia Millia Islamia
Research areas: Medicine · Oncology · Cancer Immunotherapy and Biomarkers · Immunotherapy and Immune Responses · Single-cell and spatial transcriptomics
0000-0003-1682-4824
About
I am a Computational Biologist and Bioinformatician with expertise in computational genomics, single-cell RNA sequencing, bulk RNA-seq, spatial transcriptomics, and multi-omics data integration. I obtained my Ph.D. from KU Leuven, Belgium, where I specialized in public data mining and genome-scale metabolic network modeling. My research focuses on tumor immunology, cancer genomics, and precision medicine, applying bioinformatics, machine learning, and epidemiological approaches to analyze large-scale molecular and clinical datasets. I have extensive experience developing reproducible bioinformatics workflows and collaborating with multidisciplinary teams to advance translational cancer research.
Employment
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Martin Luther University Halle-Wittenberg Bioinformatician2025 - Present
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Herlev Hospital National Center for Cancer Immune Therapy Postdoctoral Fellow2020 - 2025
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Jawaharlal Nehru University Project assistant2010 - 2012
Education
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KU Leuven Ph.D. (Bioinformatics)2016 - 2016
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University of Paris-Saclay Master in systems and synthetic biology2015 - 2016
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Jamia Millia Islamia M.Sc. (Bioinformatics)2008 - 2010
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Aligarh Muslim University B.Sc. (Physics)2002 - 2005
Projects & Funding
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Development of Endothelial Eell transcriptomics data database Kom op tegen Kanker2017 - 2018
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Master programs in France University of Paris-Saclay2015 - 2016
Publications (32)
- Five‐year survival impact of adjuvant anti‐PD‐1 therapy in a nationwide cohort of stage III melanoma Save
- Perturb-seq reveals TCF7 as a transcriptional link between MAPK- and Wnt-driven gene expression Save
- Progression risk among responders to PD-1/PD-L1 blockade is primarily stratified by response depth: A nationwide cohort study of 2127 patients with melanoma, RCC, and NSCLC. Save
- Prospective study of patients with immune checkpoint inhibitor-induced hepatitis; characterization of liver injury, outcome of therapy, and management of steroid-unresponsive and steroid-dependent hepatitis Save
- Potential Role of Tumor-derived MIF in B-Cell Antigen Presentation in Lung Adenocarcinoma: Single-cell and TCGA Analyses. Save
- Dabrafenib/trametinib versus encorafenib/binimetinib in BRAF-mutant metastatic melanoma: a real-world propensity score matched survival analysis Save
- Network-based clustering and statistical evaluation to elucidate structure-activity relationships of EZH2 inhibitors. Save
- E3 ubiquitin ligases and their therapeutic potential in disease Management Save
- The antitumor activity of TGFβ-specific T cells is dependent on IL-6 signaling Save
- Molecular Landscape of Bladder Cancer: Key Genes, Transcription Factors, and Drug Interactions Save
- PD-L1 is a biomarker of real-world clinical outcomes for anti-CTLA-4 plus anti-PD-1 or anti-PD-1 monotherapy in metastatic melanoma Save
- Spatial transcriptomics data and analytical methods: An updated perspective. Save
- Dissecting tumor microenvironment heterogeneity in syngeneic mouse models: insights on cancer-associated fibroblast phenotypes shaped by infiltrating T cells. Save
- From cancer big data to treatment: Artificial intelligence in cancer research Save
- Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast. Save
- Chitooligosaccharides Improve the Efficacy of Checkpoint Inhibitors in a Mouse Model of Lung Cancer. Save
- Mitochondrial respiration supports autophagy to provide stress resistance during quiescence. Save
- Rapid Identification of the Tumor-Specific Reactive TIL Repertoire via Combined Detection of CD137, TNF, and IFNγ, Following Recognition of Autologous Tumor-Antigens. Save
- Tumor vessel co-option probed by single-cell analysis. Save
- Loss of Ambra1 promotes melanoma growth and invasion. Save