Luca Di Leo

Employment

• Danish Cancer Society PostDoc Position
  2018 - Present

Education

• Universita degli Studi di Roma Tor Vergata PhD
  2014 - 2017

Projects & Funding

Projects & funding information is unavailable.

Publications (22)

• Inhibition of ABCG2 by SCO-101 Enhances Chemotherapy Efficacy in Cancer
  International Journal of Molecular Sciences 2025 DOI: 10.3390/ijms26083790
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• AMBRA1 levels predict resistance to MAPK inhibitors in melanoma
  Luca Di Leo, Chiara Pagliuca, Ali Kishk +18 more
  Proceedings of the National Academy of Sciences 2024 DOI: 10.1073/pnas.2400566121
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• Metabolic modelling-based in silico drug target prediction identifies six novel repurposable drugs for melanoma
  Cell Death & Disease 2023 DOI: 10.1038/s41419-023-05955-1
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• Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma
  Alex Frías, Luca Di Leo, Asier Antoranz

  +16 more

  • Loulieta Nazerai
  • Marco Carretta
  • Valérie Bodemeyer
  • Chiara Pagliuca
  • Christina Dahl
  • +11 more
  Journal for ImmunoTherapy of Cancer 2023 DOI: 10.1136/jitc-2022-006389
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• GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation.
  Salvatore Rizza, Luca Di Leo, Chiara Pecorari +15 more
  Cell reports 2023 DOI: 10.1016/j.celrep.2023.111997
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• Thiopurine 6TG treatment increases tumor immunogenicity and response to immune checkpoint blockade.
  Loulieta Nazerai, Shona Caroline Willis, Patricio Yankilevich

  +12 more

  • Luca Di Leo
  • Francesca Maria Bosisio
  • Alex Frías
  • Corine Bertolotto
  • Jacob Nersting
  • +7 more
  Oncoimmunology 2022 DOI: 10.1080/2162402x.2022.2158610
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• New Insights into the Phenotype Switching of Melanoma
  Cancers 2022 DOI: 10.3390/cancers14246118
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• The Cancermuts software package for the prioritization of missense cancer variants: a case study of AMBRA1 in melanoma
  Matteo Tiberti, Luca Di Leo, Mette Vixø Vistesen +4 more
  Cell Death & Disease 2022 DOI: 10.1038/s41419-022-05318-2
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• AMBRA1 and FAK1: crosstalking for improved targeted therapy in melanoma
  Molecular & Cellular Oncology 2021 DOI: 10.1080/23723556.2021.1949955
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• AMBRA1 has an impact on melanoma development beyond autophagy
  Autophagy 2021 DOI: 10.1080/15548627.2021.1940608
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• Loss of Ambra1 promotes melanoma growth and invasion
  Luca Di Leo, Valérie Bodemeyer, Francesca Maria Bosisio +20 more
  Nature Communications 2021 DOI: 10.1038/s41467-021-22772-2
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• AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.
  Emiliano Maiani, Giacomo Milletti, Francesca Nazio +43 more
  Nature 2021 DOI: 10.1038/s41586-021-03422-5
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• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
  Daniel J. Klionsky, Amal Kamal Abdel‐Aziz, Sara Abdelfatah +97 more
  Autophagy 2021 DOI: 10.1080/15548627.2020.1797280
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• Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS/FoxO1-mediated autophagic response
  Fabio Ciccarone, Luca Di Leo, Giacomo Lazzarino +4 more
  British Journal of Cancer 2020 DOI: 10.1038/s41416-019-0641-0
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• Mitophagy contributes to alpha-tocopheryl succinate toxicity in GSNOR-deficient hepatocellular carcinoma
  Salvatore Rizza, Luca Di Leo, Sara Mandatori +2 more
  Biochemical Pharmacology 2020 DOI: 10.1016/j.bcp.2020.113885
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• The Complex Role of Autophagy in Melanoma Evolution: New Perspectives From Mouse Models
  Frontiers in Oncology 2020 DOI: 10.3389/fonc.2019.01506
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• Forcing ATGL expression in hepatocarcinoma cells imposes glycolytic rewiring through PPAR-α/p300-mediated acetylation of p53
  Oncogene 2019 DOI: 10.1038/s41388-018-0545-0
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• Hints on ATGL implications in cancer: Beyond bioenergetic clues
  Cell Death and Disease 2018 DOI: 10.1038/s41419-018-0345-z
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• Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells
  Cell Death and Disease 2018 DOI: 10.1038/s41419-018-1065-0
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• TCA cycle aberrations and cancer
  Encyclopedia of Cancer 2018 DOI: 10.1016/B978-0-12-801238-3.65066-3
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