RY
Rui Yang
Baylor College of Medicine, Rockefeller University, University of Vermont, Huazhong University of Science and Technology Tongji Medical College, NewYork–Presbyterian Hospital
Research areas: Immunology and Microbiology · Immunology · Immunodeficiency and Autoimmune Disorders · T-cell and B-cell Immunology · Advanced Drug Delivery Systems
0000-0003-4427-2158
Employment
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Baylor College of Medicine Clinical Fellow2024 - Present
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Rockefeller University Visiting Fellow2021 - Present
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NewYork–Presbyterian Hospital Resident House Staff2021 - 2024
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Rockefeller University Postdoc2016 - 2021
Education
- 2011 - 2016
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Huazhong University of Science and Technology Tongji Medical College2006 - 2011
Projects & Funding
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CD40LG copy-number gains associated autoimmune disease Jeffrey Modell Foundation2026 - 2027
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Genetic and Immunological Mechanisms of the CD27–CD70 Axis in Lymphoma National Cancer Institute2026 - 2027
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Inherited T-BET deficiency in Mendelian Susceptibility to Mycobacterial Disease Immune Deficiency Foundation2019 - 2020
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Molecular and cellular dissection of inherited BTN3A3 Stony Wold-Herbert Fund2018 - 2020
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Molecular and cellular dissection of inherited T-bet deficiency in the pathogenesis of MSMD Rockefeller University Pilot Project by the Shapiro-Silverberg Fund2018 - 2019
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Molecular and cellular dissection of inherited BTN3A3 deficiency in the pathogenesis of human tuberculosis Rockefeller University Sackler Center for Biomedicine and Nutrition2017 - 2018
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2015 Careers in Immunology Fellowship American Association of Immunologists2015 - 2016
Publications (45)
- Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity Save
- Genetic Testing in Clinical Immunology: What to Know and How to Do It Save
- JAK Inhibition in PNPT1-Related Mitochondrial Interferonopathy: A Case Report and Review of Mitochondrial-Immune Crosstalk. Save
- Key and Emerging Concepts in Inborn Errors of Immunity and Immune Dysregulation. Save
- Distinct EBV-Associated Phenotypes Due to a Novel Homozygous Missense Variant in CD27 Save
- Human LY9 governs CD4 + T cell IFN-γ immunity to Mycobacterium tuberculosis Save
- Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling. Save
- Tuberculosis in otherwise healthy adults with inherited TNF deficiency Save
- Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 or 16:02 individuals Save
- Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria. Save
- Genotyping MUltiplexed-Sequencing of CRISPR-Localized Editing (GMUSCLE): An Experimental and Computational Approach for Analyzing CRISPR-Edited Cells. Save
- Inborn errors of human transcription factors governing IFN-γ antimycobacterial immunity. Save
- Human IL-23 is essential for IFN-γ-dependent immunity to mycobacteria. Save
- Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria. Save
- Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis Save
- Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency Save
- Human T-bet governs the generation of a distinct subset of CD11c high CD21 low B cells Save
- Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation. Save
- Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin. Save
- The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies. Save