MH
Melissa Holstein
Bristol-Myers Squibb Co, EMD Millipore Co Bedford, Rensselaer Polytechnic Institute
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Protein purification and stability · Analytical Chemistry and Chromatography · Viral Infectious Diseases and Gene Expression in Insects
0000-0001-8370-123X
Employment
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Bristol-Myers Squibb Co2018 - Present
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EMD Millipore Co Bedford2012 - 2018
Education
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Rensselaer Polytechnic Institute B.S., Ph.D.
Projects & Funding
Projects & funding information is unavailable.
Publications (28)
- A case study showing the role of hydrophobicity variants and other enriched mAb proteoforms on filterability through a virus filter with productivity improvement measures Save
- Understanding the Impact of Combined Hydrodynamic Shear and Interfacial Dilatational Stress, on Interface-Mediated Particle Formation for Monoclonal Antibody Formulations Save
- Use of Monte Carlo simulations for improved facility fit planning in downstream biomanufacturing and technology transfer Save
- Assessing detergent‐mediated virus inactivation, protein stability, and impurity clearance in biologics downstream processes Save
- Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes Save
- Virus inactivation at moderately low pH varies with virus and buffer properties Save
- Affinity precipitation of monoclonal antibodies using ELP-Z in the elution without resolubilization mode Save
- Physiochemical properties of enveloped viruses and arginine dictate inactivation Save
- Process analytical technology for on‐line monitoring of quality attributes during single‐use ultrafiltration/diafiltration Save
- Using continuous chromatography methodology to achieve high-productivity and high-purity enrichment of charge variants for analytical characterization Save
- Antibody retention by virus filtration membranes: Polarization and sieving effects Save
- Control of leached beta‐glucan levels from depth filters by an improved depth filtration flush strategy Save
- Real‐time monitoring of quality attributes by in‐line Fourier transform infrared spectroscopic sensors at ultrafiltration and diafiltration of bioprocess Save
- Strategies for high-concentration drug substance manufacturing to facilitate subcutaneous administration: A review Save
- Continuous In-Line Virus Inactivation for Next Generation Bioprocessing Save
- Protein a intermediate wash strategies Save
- Effects of urea on selectivity and protein-ligand interactions in multimodal cation exchange chromatography Save
- Theoretical investigations of multiple weak interactions in multimodal chromatography using molecular dynamics simulations and protein surface characterization Save
- Theoretical investigations of multiple weak interactions in multimodal chromatography using molecular dynamics simulations and protein surface characterization Save
- Improving selectivity in multimodal chromatography using controlled pH gradient elution Save