Hasin Feroz
Moderna Therapeutics Inc, Bristol-Myers Squibb, Pennsylvania State University Penn State World Campus, Bangladesh University of Engineering and Technology
Research areas: Biochemistry, Genetics and Molecular Biology · Molecular Biology · Protein purification and stability · Membrane Separation Technologies · Lipid Membrane Structure and Behavior
About
Hasin Feroz's doctoral research primarily focuses on the biophysical characterization of a unique class of bio-medically relevant light-driven membrane proteins called rhodopsins. Recognizing early on the challenges associated with obtaining high yields of purified membrane proteins, she has developed strategies for optimizing the extraction and ultrafiltration-based concentration of these proteins to remove the bottleneck associated with their characterization. She has also implemented experimental and model-based approaches to predict the performance of membranes for ultrafiltration / microfiltration applications in water treatment and sterilization. In the course of her Ph.D., she has been deeply involved in teaching and mentoring undergraduate researchers which has been an integral part of her teaching and research experience at Penn State. Hasin Feroz has been s a downstream process scientist at BMS and is now currently at Moderna where she develops and characterizes new therapeutic processes of different modalities through a Design of Experiment (DoE) approach. She supports tech transfer and scale-up for clinical phase therapeutics. As part of continuous platform evolution for ultrafiltration/ diafiltration, she evaluates new technologies including Process Analytical Technology (PAT), Fourier Transform Infrared microscopy (FTIR) and single-use tangential flow filtration devices. She also leads academic collaboration to understand fundamental mechanism of virus inactivation. Her current research focuses on developing analytical methods to evaluate surrogates and screen candidates for virus inactivation. She has also taught undergrad classes on filtration applications in industrial bioseparation at UMass Lowell from 2018 to 2021.
Employment
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Moderna Therapeutics Inc Senior scientist2021 - Present
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Bristol-Myers Squibb Scientist I2018 - Present
- 2012 - 2012
Education
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Pennsylvania State University Penn State World Campus Ph.D.2012 - Present
- 2007 - 2012
Projects & Funding
Projects & funding information is unavailable.
Publications (12)
- The role of intermolecular interactions on monoclonal antibody filtration through virus removal membranes Save
- Use of Monte Carlo simulations for improved facility fit planning in downstream biomanufacturing and technology transfer Save
- Assessing detergent‐mediated virus inactivation, protein stability, and impurity clearance in biologics downstream processes Save
- Role of membrane structure on the filtrate flux during monoclonal antibody filtration through virus retentive membranes Save
- Virus inactivation at moderately low pH varies with virus and buffer properties Save
- Surrogate model to screen for inactivation‐based clearance of enveloped viruses during biotherapeutics process development Save
- Assessing detergent-mediated virus inactivation, protein stability and impurity clearance in biologics downstream processes Save
- Physiochemical properties of enveloped viruses and arginine dictate inactivation Save
- Establishing a surrogate model for inactivation of enveloped viruses to screen viral clearance conditions during biotherapeutics process development Save
- Strategies for high‐concentration drug substance manufacturing to facilitate subcutaneous administration: A review Save
- Rapid screening and scale‐up of ultracentrifugation‐free, membrane‐based procedures for purification of His‐tagged membrane proteins Save
- Improving extraction and post-purification concentration of membrane proteins Save