Hirdesh Kumar
United States Food and Drug Administration, National Institute of Health, University Hospital Heidelberg, Indian Institute of Technology Delhi, Washington University in Saint Louis School of Medicine
Research areas: Medicine · Public Health, Environmental and Occupational Health · Malaria Research and Control · Bird parasitology and diseases · Antibiotic Resistance in Bacteria
0000-0002-8488-3001
About
My goal is to develop the small-molecules therapeutics and vaccine against human diseases. Using the tools of microbiology, cell biology, biochemistry, biophysics and structural biology to study mechanisms of action, and inhibition, I have studied therapeutic agents against different diseases.
Employment
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U.S. Food and Drug Administration CMC Reviewer2023 - Present
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Codexis (United States) Structural Bioinformatician2022 - 2023
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National Institute of Health Postdoctoral Fellow2018 - Present
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Washington University in Saint Louis School of Medicine Postdoctoral Research Associate2016 - Present
Education
- 2015 - 2016
- 2009 - Present
- 2007 - 2009
Projects & Funding
Projects & funding information is unavailable.
Publications (17)
- BioLindlar Catalyst: Ene‐Reductase‐Promoted Selective Bioreduction of Cyanoalkynes to Give (Z)‐Cyanoalkenes Save
- BioLindlar Catalyst: Ene‐Reductase‐Promoted Selective Bioreduction of Cyanoalkynes to Give (Z)‐Cyanoalkenes Save
- Implications of conformational flexibility, lipid binding, and regulatory domains in cell-traversal protein CelTOS for apicomplexan migration Save
- Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance Save
- A function of profilin in force generation during malaria parasite motility that is independent of actin binding. Save
- Getting in: The structural biology of malaria invasion Save
- Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes Save
- Functional genetic evaluation of DNA house-cleaning enzymes in the malaria parasite: dUTPase and Ap4AH are essential in Plasmodium berghei but ITPase and NDH are dispensable Save
- Inter-subunit interactions drive divergent dynamics in mammalian and Plasmodium actin filaments Save
- A unique profilin-actin interface is important for malaria parasite motility Save
- Malaria parasite LIMP protein regulates sporozoite gliding motility and infectivity in mosquito and mammalian hosts Save
- Pharmacophore generation and atom based 3D-QSAR of quinoline derivatives as selective phosphodiesterase 4B inhibitors Save
- Protective efficacy and safety of liver stage attenuated malaria parasites Save
- In silico identification of genetically attenuated vaccine candidate genes for Plasmodium liver stage Save
- Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis Save
- Novel insights into the structural requirements for the design of selective and specific aldose reductase inhibitors Save
- Insights into the Structural Requirements of PKCβII Inhibitors Based on HQSAR and CoMSIA Analyses Save