John Jimah

About

My main scientific interest is investigating the structure, function and mechanism of human and microbial proteins, especially those relevant to human disease.

Specific research interests/focus include: the structure/mechanism of membrane remodeling proteins, structural cell biology of malaria parasites, membrane and peripheral membrane proteins, and cryo-electron microscopy/tomography.

Employment

• Princeton University Assistant Professor
  2022 - Present
• National Institutes of Health Postdoctoral Fellow in the lab of Jenny Hinshaw
  2017 - 2022

Education

• Washington University in Saint Louis PhD in Biomedical Sciences - Molecular Microbiology and Microbial Pathogenesis
  2011 - 2017
• Colgate University BA in Molecular Biology
  2004 - 2008

Projects & Funding

• Structural basis of dynamin-mediated membrane fission actin bundling and interaction with binding partners. National Institute of General Medical Sciences
  2022 - 2025

Publications (33)

• Multistage protective anti-CelTOS monoclonal antibodies with cross-species sterile protection against malaria.
  Wai Kwan Tang, Nichole D. Salinas, Surendra Kumar Kolli +9 more
  Nature communications 2024 DOI: 10.1038/s41467-024-51701-2
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• Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission.
  Developmental cell 2024 DOI: 10.1016/j.devcel.2024.04.008
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• CryoEM Structures of Dynamin Proteins Involved in Membrane Fission and Fusion.
  Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023 DOI: 10.1093/micmic/ozad067.451
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• Implications of conformational flexibility, lipid binding, and regulatory domains in cell-traversal protein CelTOS for apicomplexan migration
  Hirdesh Kumar, John R. Jimah, Santosh A. Misal

  +4 more

  • Nichole D. Salinas
  • Michal Fried
  • Paul H. Schlesinger
  • Niraj Harish Tolia
  Journal of Biological Chemistry 2022 DOI: 10.1016/j.jbc.2022.102241
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• Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin.
  Biomolecules 2022 DOI: 10.3390/biom12040584
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• BamABCDE bound to substrate EspP
  2022 DOI: 10.2210/pdb7ttc/pdb
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• BamABCDE bound to substrate EspP class 1
  2022 DOI: 10.2210/pdb7tsz/pdb
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• BamABCDE bound to substrate EspP class 2
  2022 DOI: 10.2210/pdb7tt0/pdb
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• BamABCDE bound to substrate EspP class 3
  2022 DOI: 10.2210/pdb7tt2/pdb
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• BamABCDE bound to substrate EspP class 4
  2022 DOI: 10.2210/pdb7tt1/pdb
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• BamABCDE bound to substrate EspP class 5
  2022 DOI: 10.2210/pdb7tt3/pdb
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• BamABCDE bound to substrate EspP class 6
  2022 DOI: 10.2210/pdb7tt4/pdb
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• BamABCDE bound to substrate EspP in the barrelized EspP/continuous open BamA state
  2022 DOI: 10.2210/pdb7tt7/pdb
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• BamABCDE bound to substrate EspP in the intermediate-open EspP state
  2022 DOI: 10.2210/pdb7tt6/pdb
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• BamABCDE bound to substrate EspP in the open-sheet EspP state
  2022 DOI: 10.2210/pdb7tt5/pdb
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• Conformational flexibility, lipid binding, and regulatory domains in CelTOS
  Hirdesh Kumar, John R. Jimah, Francis Babila Ntumngia +6 more
  2022 DOI: 10.1101/2022.03.31.486524
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• Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding
  Cell 2022 DOI: 10.1016/j.cell.2022.02.016
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• The structure and spontaneous curvature of clathrin lattices at the plasma membrane
  Developmental Cell 2021 DOI: 10.1101/2020.07.18.207258
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• Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.
  Nature cell biology 2020 DOI: 10.1038/s41556-020-0519-7
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• Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation
  JCI Insight 2020 DOI: 10.1172/jci.insight.134010
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