Santosh A. Misal

About

Dr. Santosh A. Misal is a distinguished scientist at the National Institutes of Health, Bethesda MD USA. He has a strong background in protein biochemistry, proteomics, and mass spectrometry. Dr. Misal has developed advanced techniques for single-cell proteomic analysis, particularly, single neuron analysis from healthy and ALS patients, which are crucial for precision medicine research. Dr. Misal’s work has significantly advanced the mass spectrometry and proteomics field, making him a notable figure in biomedical research.

Employment

• National Institutes of Health Staff Scientist
  2021 - Present
• Brigham Young University Research Associate
  2019 - 2021
• Indiana University Bloomington Postdoctoral Research associate
  2014 - 2018
• Institut de recherches cliniques de Montréal Postdoctoral research fellow
  2011 - 2013

Education

• Savitribai Phule Pune University PhD
  2007 - 2012

Projects & Funding

Projects & funding information is unavailable.

Publications (19)

• TDP-43-stratified single-cell proteomics of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis
  Cell Reports 2024 DOI: 10.1016/j.celrep.2023.113636
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• Non-Specific Signal Peptidase Processing of Extracellular Proteins in Staphylococcus aureus N315
  Proteomes 2023 DOI: 10.3390/proteomes11010008
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• TDP-43-stratified single-cell proteomic profiling of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis
  bioRxiv 2023 DOI: 10.1101/2023.06.08.544233
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• Conformational flexibility, lipid binding, and regulatory domains in CelTOS
  Hirdesh Kumar, John R. Jimah, Francis Babila Ntumngia +6 more
  bioRxiv 2022 DOI: 10.1101/2022.03.31.486524
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• Implications of conformational flexibility, lipid binding, and regulatory domains in cell-traversal protein CelTOS for apicomplexan migration
  Hirdesh Kumar, John R. Jimah, Santosh A. Misal

  +4 more

  • Nichole D. Salinas
  • Michal Fried
  • Paul H. Schlesinger
  • Niraj Harish Tolia
  Journal of Biological Chemistry 2022 DOI: 10.1016/j.jbc.2022.102241
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• In-Depth Mass Spectrometry-Based Proteomics of Formalin-Fixed, Paraffin-Embedded Tissues with a Spatial Resolution of 50-200 μm
  Journal of Proteome Research 2022 DOI: 10.1021/acs.jproteome.2c00409
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• Interpretation of anomalously long crosslinks in ribosome crosslinking reveals the ribosome interaction in stationary phase E. coli
  RSC Chemical Biology 2022 DOI: 10.1039/d2cb00101b
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• Single-Cell Proteome Profiling of Neuronal Cells
  Neuromethods 2022 DOI: 10.1007/978-1-0716-2525-5_3
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• Ultrasensitive single-cell proteomics workflow identifies >1000 protein groups per mammalian cell
  Chemical Science 2021 DOI: 10.1039/d0sc03636f
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• Ultrasensitive single-cell proteomics workflow identifies >1000 protein groups per mammalian cell
  bioRxiv 2020 DOI: 10.1101/2020.06.03.132449
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• Identification of N‐terminal protein processing sites by chemical labeling mass spectrometry
  Rapid Communications in Mass Spectrometry 2019 DOI: 10.1002/rcm.8435
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• Azoreductase: a key player of xenobiotic metabolism
  Bioresources and Bioprocessing 2018 DOI: 10.1186/s40643-018-0206-8
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• Impact of Amidination on Peptide Fragmentation and Identification in Shotgun Proteomics
  Journal of Proteome Research 2016 DOI: 10.1021/acs.jproteome.6b00468
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• Enzymatic transformation of nitro-aromatic compounds by a flavin-free NADH azoreductase from Lysinibacillus sphaericus
  Santosh A. Misal, Devendra P. Lingojwar, Mahendra N. Lokhande

  +2 more

  • Pradeep D. Lokhande
  • Kachru R. Gawai
  Biotechnology Letters 2014 DOI: 10.1007/s10529-013-1338-8
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• Properties of NAD (P) H Azoreductase from Alkaliphilic Red Bacteria Aquiflexum sp DL6
  Protein Journal 2013 DOI: 10.1007/s10930-013-9522-1
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• Purification and Characterization of Nitroreductase from Red Alkaliphilic Bacterium Aquiflexum sp DL6
  Applied Biochemistry and Microbiology 2013 DOI: 10.1134/S0003683813030125
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• Purification and characterization of nitroreductase from red alkaliphilic bacterium Aquiflexum sp. DL6.
  Prikladnaia Biokhimiia I Mikrobiologiia 2013
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• Purification and characterization of nitroreductase from red alkaliphilic bacterium Aquiflexum sp. DL6.
  Prikladnaia biokhimiia i mikrobiologiia 2013 DOI: 10.7868/S0555109913030124
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• Purification and characterization of azoreductase from alkaliphilic strain Bacillus badius
  Process Biochemistry 2011 DOI: 10.1016/j.procbio.2011.02.013
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